Bingham fluid simulations using a physically consistent particle method

The Bingham fluid simulation model was constructed and validated using a physically consistent particle method, i.e., the Moving Particle Hydrodynamics (MPH) method. When a discrete particle system satisfies the fundamental laws of physics, the method is asserted as physically consistent. Since Bingham fluids sometimes show solid-like behaviors, linear and angular momentum conservation is especially important. These features are naturally satisfied in the MPH method. To model the Bingham feature, the viscosity of the fluid was varied to express the stress-strain rate relation. Since the solid-like part, where the stress does not exceed the yield stress, was modeled with very large viscosity, the implicit velocity calculation was introduced so as to avoid the restriction of the time step width with respect to the diffusion number. As a result, the present model could express the stopping and solid-like behaviors, which are characteristics of Bingham fluids. The proposed method was verified and validated, and its capability was demonstrated through calculations of the two-dimensional Poiseuille flow of a Bingham plastic fluid and the three-dimensional dam-break flow of a Bingham pseudoplastic fluid by comparing those computed results to theory and experiment

Interferon-α and Interleukin-12 Are Induced Differentially by Toll-like Receptor 7 Ligands in Human Blood Dendritic Cell Subsets

Dendritic cells (DCs) play a crucial role in the immune responses against infections by sensing microbial invasion through toll-like receptors (TLRs). In humans, two distinct DC subsets, CD11c− plasmacytoid DCs (PDCs) and CD11c+ myeloid DCs (MDCs), have been identified and can respond to different TLR ligands, depending on the differential expression of cognate TLRs. In this study, we have examined the effect of TLR-7 ligands on human DC subsets. Both subsets expressed TLR-7 and could respond to TLR-7 ligands, which enhanced the survival of the subsets and upregulated the surface expression of costimulatory molecules such as CD40, CD80, and CD86. However, the cytokine induction pattern was distinct in that PDCs and MDCs produced interferon (IFN)-α and interleukin (IL)-12, respectively. In response to TLR-7 ligands, the Th1 cell supporting ability of both DC subsets was enhanced, depending on the cytokines the respective subsets produced. This study demonstrates that TLR-7 exerts its biological effect in a DC subset-specific manner

Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

AbstractCD30 is found on Reed–Sternberg cells of Hodgkin's disease and on a variety of non-Hodgkin's lymphoma cells and is up-regulated on cells after Epstein–Barr virus, human T cell leukemia virus, and HIV infections. We report here that the thymus in CD30-deficient mice contains elevated numbers of thymocytes. Activation-induced death of thymocytes after CD3 cross-linking is impaired both in vitro and in vivo. Breeding the CD30 mutation separately into αβTCR- or γδTCR-transgenic mice revealed a gross defect in negative but not positive selection. Thus, like TNF-receptors and Fas/Apo-1, the CD30 receptor is involved in cell death signaling. It is also an important coreceptor that participates in thymic deletion

A fluid lubrication analysis including negative pressure using a physically consistent particle method

In recent years, particle methods, which are good for moving boundary problems, have become an effective approach to understand and predict flows in complex geometry, such as lubrication behaviors in rolling bearings. This study adopted a physically consistent particle method, i.e., the moving particle hydrodynamics for incompressible flows (MPH-I) method. For capturing the free surface flows in lubrication, a surface tension model was included. In order to maintain the physical consistency in the MPH-I method, the surface tension model expressed with the two density potentials, which are cohesive pressure potential (CPP) and density gradient potential (DGP), was adopted. The MPH-I method with the two-potential-based surface tension model enabled to handle negative pressure and nearly incompressible flow with very large bulk modulus. In fact, the MPH-I method could successfully reproduce fundamental pressure generation effects in the fluid film lubrication, i.e., the wedge film and squeeze film effects. Furthermore, the computed lubrication pressure agreed well with the experimental results and the classic prediction with Reynolds equation. This implies that the present numerical method was validated under the fluid film lubrication problems

Impact Tensile Properties of Notched Titanium Alloy Bolt for Fairing Separation of Launch Vehicle

The payload fairing in Japan is fixed by a lot of notched bolts. These notched bolts were fractured by axial impact tensile using the explosive devices to separate the fairing. In this case, the stress waves and the oscillations propagate, which may seriously damage the satellites. In this study, the impact deformation and the fracture behavior of notched titanium alloy bolt was investigated using a split Hopkinson pressure bar method. The notched bolt specimen was made of commercial Ti-6Al-4V alloy. The maximum load value was increased with increasing the displacement rate. It can be said that the strain rate dependence of strength for Ti-6Al-4V alloy appeared. From the observation of fracture surface using a scanning electron microscope, compared with the quasi-static test, it was clear that the irregularities of the fractured surface at the impact tensile test became rough. Therefore, it was found that the brittle fracture was mainly observed due to the increase in displacement rate, which may mean that the mode of fracture changes from the transgranular to the intergranular. It was surmised that this change of fracture mode was caused by the high strain rate due to stress concentration of the notched part

Impact Tensile Properties of Notched Titanium Alloy Bolt for Fairing Separation of Launch Vehicle

The payload fairing in Japan is fixed by a lot of notched bolts. These notched bolts were fractured by axial impact tensile using the explosive devices to separate the fairing. In this case, the stress waves and the oscillations propagate, which may seriously damage the satellites. In this study, the impact deformation and the fracture behavior of notched titanium alloy bolt was investigated using a split Hopkinson pressure bar method. The notched bolt specimen was made of commercial Ti-6Al-4V alloy. The maximum load value was increased with increasing the displacement rate. It can be said that the strain rate dependence of strength for Ti-6Al-4V alloy appeared. From the observation of fracture surface using a scanning electron microscope, compared with the quasi-static test, it was clear that the irregularities of the fractured surface at the impact tensile test became rough. Therefore, it was found that the brittle fracture was mainly observed due to the increase in displacement rate, which may mean that the mode of fracture changes from the transgranular to the intergranular. It was surmised that this change of fracture mode was caused by the high strain rate due to stress concentration of the notched part